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You are here: Home / Foot care / Activated protein C can stimulate wound healing in patients with skin ulcers

Activated protein C can stimulate wound healing in patients with skin ulcers

December 1, 2008 by Dr.Deepak 1 Comment

Current research suggest that Activated protein C can stimulate wound healing in patients with skin ulcers that are refractory to conventional wound-healing therapies,according to the article published in november issue of Archives of Dermatology.

The treatment of skin ulcers frequently presents a management challenge. Nonhealing wounds with poor response to conventional wound management therapy represent a significant cause of disability, affecting approximately 1% of the global population. Activated protein C is a serine protease with anticoagulant, angiogenic, and anti-inflammatory properties that has shown efficacy in patients for the treatment of severe sepsis. We report 4 cases of nonhealing lower limb skin ulcers that were treated with activated protein C.

The study included 4 patients whose wounds were not improving despite standard wound treatment for 4 months or more. Activated protein C was applied topically to their wounds once weekly for 4 weeks. All 4 patients showed a rapid positive response to treatment that was maintained during a 4-month follow-up period. The treatment was well tolerated, with no remarkable adverse effects or complications.

The likely mechanism of action is its recognized ability to stimulate angiogenesis and reepithelialization and to inhibit inflammation. Activated protein C has potential as a therapeutic option for patients with chronic skin ulcers.

Adapted from materials provided by Archives of Dermatology

Filed Under: Foot care, News, skin infection Tagged With: Activated protein C, skin infection, skin ulcer, wound healing

Reader Interactions

Comments

  1. Bryan says

    January 16, 2010 at 1:38 am

    It’s nice to know information like this. I was happy knowing this because I have a friend who is struggling in that situation. Thanks for the post!

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