Its normally last options for acne when all medications has failed..,there are many cases of birth defects like abnormalities of the eyes,ears,face, central nervous system, cardiovascular system, and thymus and parathyroid glands so you should not use it if you are pregnant or during pregnancy.
Other side effects might be slight swelling of eyelids or lips,dryness of lips,mouth and skin. sometimes gastro intestinal upset, nosebleeds. If you get of the side effects contact your doctor immediately.