Glycolic acid solution is prepared by using a 30% glycolic acid and pouring it into a spray bottle. The solution is then sprayed onto the affected area daily. Let the solution stay on the skin for several hours. Avoid washing the area applied with the solution. Although this treatment may cause a little stinging sensation, it's perfectly fine. After application, the skin starts to turn red in color, and a crust is formed on the treated spots. The spots will not be a pretty sight for some time, but the crust will eventually fall off to reveal smooth skin. For best results, the solution can be left on the skin overnight. For stubborn spots, reapply the glycolic solution after the spots have healed sufficiently from the first application. Maintenance treatments may also be needed if seborrheic keratosis growths reappear on the skin.

If it is your first time to use glycolic acid solution, start on the affected areas on your back, starting with a small section. Never apply to all parts of the body affected with seborrheic keratosis at one time. By doing only a small section at first, you can see how your skin reacts to the glycolic acid solution. If the stinging becomes unbearable--or you feel anything other than the slight stinging expected--then it is best to discontinue use.