Isotretinoin is typically prescribed for the following indications:

Severe Nodular Acne: Isotretinoin is highly effective in treating severe nodular acne, characterized by large, painful, and deeply embedded acne lesions (nodules). This is one of the most common and well-established indications for isotretinoin.

Cystic Acne: Cystic acne is a severe form of acne that involves the development of painful cysts beneath the skin's surface. Isotretinoin can help shrink these cysts and prevent new ones from forming.

Acne Resistant to Other Treatments: Isotretinoin is often considered when other treatments for acne, such as topical creams, antibiotics, or hormonal therapies, have proven ineffective or insufficient in controlling the condition.

Acne Scarring: In some cases, isotretinoin may be used to prevent further acne scarring by effectively treating severe acne and reducing the likelihood of new lesions forming.

Acne with Psychological Distress: Acne can have a significant impact on a person's emotional well-being and self-esteem. In cases where severe acne is causing psychological distress, a healthcare provider may consider isotretinoin as a treatment option.

It's important to note that isotretinoin is a powerful medication with potential side effects, and its use should be carefully monitored by a healthcare provider. The specific indication for prescribing isotretinoin is typically determined based on the severity of the patient's acne, their response to other treatments, and other individual factors.

Additionally, women of childbearing potential are required to use effective contraception while taking isotretinoin due to the risk of severe birth defects if they become pregnant during treatment. Regular follow-up appointments with a healthcare provider are essential to monitor progress and address any concerns during isotretinoin treatment.